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Methylcobalamin and Adenosylcobalamin are found in food sources as natural co-enzymes

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Hydroxocobalamin, also known as vitamin B12A, is a form of vitamin B12 that is often used in compounding pharmacies to make customized medical products

Based on empirical findings, compound 45 showed the best inhibitory activity against DPP-4 in vitro, with an IC 50 value of 78 nM